HER-2/neu is an oncogene activated in ~20% of breast carcinomas via oncogene amplification. Overexpression of HER-2/neu oncoprotein can be detected by immunohistochemistry. Qualitative scoring is most commonly used (0/1+/2+/3+). Borderline immunostaining results (2+) need to be confirmed with DNA in situ hybridization (FISH or CISH).
HER-2 negative (score 0/1+)
Borderline positive (2+)
IHC-score "3+"
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