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  Normal breast
  Non-neoplastic lesions
  Benign epithelial
   proliferations
  Fibro/myoepithelial
   tumors

  Tumors of the nipple

  Lobular neoplasia

  Intraductal prolifera-
   tive lesions

  Invasive epithelial
   tumors
     IDC ILC Other

  Mesenchymal tumors

  Hematopoetic and
   metastatic tumors

  IH-stainings, TMAs,
   FISH and CISH

Invasive lobular carcinoma

up one level
Invasive lobular carcinoma (ILC) comprises 5-20% of invasive carcinomas and its proportion is increasing. ILC is composed of non-cohesive cells individually dispersed or arranged in single-file linear patterns, ‘Indian files’, in fibrous stroma. ILC cells often surround non-malignant ducts forming so called targetoid lesions. LCIS often accompanies ILC.
Classical ILC
Tubulolobular
presenting with areas of lobular and invasive tubular growth pattern.
 
Trabecular
ILC presenting with 2-3 cell wide branching sheets of carcinoma cells.		  
Solid
Solid ILC contains large solid islets of carcinoma cells. Can e.g. be mistaken for lymphoma.
 
Alveolar
Contains loose sheets and ball-like nests of carcinoma cells. An ILC-like growth pattern can be recognized.		  
Pleomorphic
Carcinoma cells are large and highly pleomorphic. Often with prominent nucleoli. Associated with poor prognosis.
 


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