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short long WHO

  Normal breast
  Non-neoplastic lesions
  Benign epithelial
   proliferations
  Fibro/myoepithelial
   tumors

  Tumors of the nipple

  Lobular neoplasia

  Intraductal prolifera-
   tive lesions

  Invasive epithelial
   tumors

    
IDC ILC Other

  Mesenchymal tumors

  Hematopoetic and
   metastatic tumors

  IH-stainings, TMAs,
   FISH and CISH

WHO 2003 classification of Tumours of the Breast

1. Epithelial tumours

      1.1 IDC

      1.2 ILC

      1.3 Tubular

      1.4 Invasive cribriform

      1.5 Medullary

      1.6 Mucinous ca and other tumours
           with abundant mucin

            1.6.1 Mucinous ca

            1.6.2 Cystadenocarcinoma and
                    col cell mucinous ca

            1.6.3 Signet ring cell ca

      1.7 Neuroendocrine tuomurs

            1.7.1 Solid neuroendocrine ca

            1.7.2 Atypical carcionid tumour

            1.7.3 Small cell / oat cell ca

            1.7.4 Large cell neuroendocrine
                    ca

      1.8 Invasive papillary ca

      1.9 Invasive micropapillary ca

      1.10 Apocrine ca

      1.11 Metaplastic carcinomas

            1.11.1 Pure epithelial
                      metaplastic ca

                  1.11.1.1 Squamous cell ca

                  1.11.1.2 Adenoca with spin-
                               dle cell metaplasia

                  1.11.1.3 Adenosquamous ca

                  1.11.1.4 Mucoepidermoid ca

            1.11.2 Mixed epithlial/ mesen-
                      chymal metaplastic ca

      1.12 Lipid-rich ca

      1.13 Secretory ca

      1.14 Oncocytic ca

      1.15 Adenoid cystic ca

      1.16 Acinic cell ca

      1.17 Glycogen-rich clear cell ca

      1.18 Sebaceous ca

      1.19 Inflammatory ca

      1.20 Lobular neoplasia

            1.20.1 Lobular ca in situ

      1.21 Intraductal proliferative lesions

            1.21.1 Usual ductal hyperplasia

            1.21.2 Flat epithelial atypia

            1.21.3 Atypical ductal hyper-
                      plasia

            1.21.4 Ductal carcinoma in situ

      1.22 Microinvasive ca

      1.23 Intraductal papillary neoplasms

            1.23.1 Central papilloma

            1.23.2 Peripheral papilloma

            1.23.3 Atypical papilloma

            1.23.4 Intraductal papillary car-
                      cinoma

            1.23.5 Intracystic papillary ca

      1.24 Benign epithelial proliferations

            1.24.1 Adenosis including vari-
                      ants

                  1.24.1.1 Sclerosing
                               adenosis

                  1.24.1.2 Apocrine adenosis

                  1.24.1.3 Blunt duct adenosis

                  1.24.1.4 Microglandular
                               adenosis

                  1.24.1.5 Adenomyoepithelial
                               adenosis

            1.24.2 Radial scar / complex
                      sclerosing lesion

      1.25 Adenomas

            1.25.1 Tubular adenoma

            1.25.2 Lactating adenoma

            1.25.3 Apocrine adenoma

            1.25.4 Pleomorphic adenoma

            1.25.5 Ductal adenoma

 

2. Myoepithelial lesions

      2.1 Myoepitheliosis

      2.2 Adenomyoeithelial adenosis

      2.3 Adenomyoepithelioma

      2.4 Malignant myoepithelioma

 

3. Mesenchymal lesions

      3.1 Haemangioma

      3.2 Angiomatosis

      3.3 Haemangiopericytoma

      3.4 Pseudoangiomatous stromal
            hyperplasia

      3.5 Myofibroblastoma

      3.6 Fibromatosis (aggressive)

      3.7 Inflammatory myofibroblastic
            tumour

      3.8 Lipoma

            3.8.1 Angiolipoma

      3.9 Granular cell tumour

      3.10 Neurofibroma

      3.11 Schwannoma

      3.12 Angiosarcoma

      3.13 Liposarcoma

      3.14 Rhabdomyosarcoma

      3.15 Osteosarcoma

      3.16 Leiomyoma

      3.17 Leiomyosarcoma

 

4. Fibroepithelial tumours

      4.1 Fibroadenoma

      4.2 Phyllodes tumour

            4.2.1 Benign

            4.2.2 Broderline

            4.2.3 Malignant

      4.3 Periductal stromal sarcoma, low
           grade

      4.4 Mammary hamartoma

     

5. Tumours of the nipple

      5.1 Nipple adenoma

      5.2 Syringomatous adenoma

      5.3 Paget disease of the nipple

 

6. Malignant lymphoma

      6.1 Diffuse large B-cell lymphoma

      6.2 Burkitt lymphoma

      6.3 Extranodal marginal-zone B-cell
            lymphoma of MALT type

      6.4 Follicular lymphoma

 

7. Metastatic tumours

 

8. Tumours of the male breast

      8.1 Gynecomastia

      8.2 Carcinoma

            8.2.1 Invasive

            8.2.2 In situ

 

 


 

Adapted from WHO, Tumours of the Breast and Female Genital Organs. IARCPress, 2003


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