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short long WHO

  Normal breast
  Non-neoplastic lesions
  Benign epithelial
   proliferations
  Fibro/myoepithelial
   tumors

  Tumors of the nipple

  Lobular neoplasia

  Intraductal prolifera-
   tive lesions

  Invasive epithelial
   tumors

    
IDC ILC Other

  Mesenchymal tumors

  Hematopoetic and
   metastatic tumors

  IH-stainings, TMAs,
   FISH and CISH

The web-site and the viewing interface
Please refer to the published article for information regarding the web-site
and the viewing interface. Here you can find details on some topics that
are only briefly described in the article:

The web-site: The web-site was constructed using standard HTML coding
combined with server-side coding. The image indexing system was integrated
into the web-site, sotring and displaying all image data, associated text sections
and annotations.

Supported browsers: Currently MS Internet Explorer or Netscape 7.1 on
the Windows platform. Netscape 7.1 on Macintosh OS X is in the beta-testing
phase. Please check back to obtain more information.

A browser plug-in: Is needed for fast communication between the user's
browser and the image server.

Installation of the plug-in: Is usually automatic, but if the user is logged into his
computer without rights to install software, the web-site will prompt for a manual
installation.

Uninstallation of the plug-in: The plugin can be uninstalled with the standard
MS Windows procedure (control panel/Add or Remove programs).

Zooming: As described in the article, the virtual slides can be zoomed in
4 ways. The most simple is to click on the predefined zoom level buttons with
the mouse, thus zooming to magnifications resembling the standard microscope
objectives. There is also an incremented keyboard zooming, requested by
pathologists during a beta-testing session. An area-of-interest can be zoomed
to by drawing a box with the mouse in zoom-box mode , and perhaps the
most innovative zooming  option is the stepless zooming with the mouse.
By holding down the left mouse button in zoom-mode while moving the
mouse forward zooms in to any magnification level, and moving the mouse
backwards zooms out. The tool restores the initial view. A descriptive
demo can be found below:
                                                      


Please note that by holding both mouse buttons pressed or by
holding the 'shift' key pressed, the pointer mode is conveniently
switched between pan and zoom!


Magnification: The actual magnification level when an image with a 0.26
um resolution is diplayed on a standard computer screen (96 dpi) is around
960:1. When we defined the zoom levels we assumed a 24 inch viewing
distance from the monitor, and since in optical systems 1X magnification usually
means the angular field of view at a distance of 10 inches, the subjective
magnification is 960 / 24 * 10 = 400x. This corresponds to a 40x objective with a
10x eyepiece. We therefore defined the maximum zoom level as '40x', and the
lower zoom levels were scaled thereafter.

Panning:  The deafult pointer mode in the viewing window is the 'hand' .
In this mode you can pan the slide by holding the left mouse button pressed. As
requested by pathologists, we have also provided navigation with the cursor
keys. The scroll speed can be adjusted in the browser, and the scroll direction
can be reversed. A very fast way of navigating a slide is by clicking the desired
view area in the small overview window. The large window will immediately
update the view.

Contrast and brightness adjustment: This is a new feature of the viewing
interface. Since there is always a slight illumination and color temperature
variation from one slide to another, the possibility to quickly adjust the
contrast and brightness come in handy. The adjustment option can also
compensate for monitor-dependent variations.

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