|
|
 |
  |
 |
|
|
|
|
|
 |
21st European Congress of Pathology
Istanbul, Turkey, September 08-13, 2007
http://www.ecp2007istanbul.org/
Slide Seminar 10, September 12th
Benign Hematopoetic Proliferations Mimicking Malignancies and Borderline Lymphoproliferative Lesions
Chairpersons: P. Kurtin, İ. Kuzu |
|
|
|
Case 1
Presented by: José Cabeçadas
Clinical History
Male, 14 years old, from West Africa with a history of malaria and generalized lymphadenopathy. He was admitted with high fever, generalized lymphadenopathy and hepatosplenomegaly. An inguinal lymph node was removed (case submitted). The patient did not respond to steroids and had 5 courses of an antracyclin based chemotherapy regimen, with complete remission. He relapsed five years later with the same histological picture in the cervical lymph nodes. He was treated with steroids and is well with a slightly depressed immune system.
|
|
Diagnosis & discussion |
|
|
|
|
Case 2
Presented by: Philippe Gaulard
Clinical History
A 14 year-old boy, originating from Marrocco, was admitted for massive splenomegaly without hepatomegaly. Physical examination disclosed micro-polyadenopathies which were already present 2 years before (To note, a lymph node biopsy performed at that time had been interpreted as showing non specific changes with follicular and paracortical hyperplasia). WBC count was normal except for mild thrombocytosis. Other investigations disclosed IgA deficiency and deficiency in X factor. The mother had a past history of idiopathic thrombocytopenia.
A splenectomy was performed: the spleen weighted 1650 g, was congestive without gross lesions. The images are from the spleen .
Five months after splenectomy, the patient developped severe acute hepatitis which was treated by steroids. Three years after, the patient is well with persistent mild peripheral adenopathies.
|
|
Diagnosis & discussion |
|
|
|
|
Case 3
Presented by: Paul Kurtin
Clinical History
The patient is a 22 year old male who presented with a 1 week history of sore throat, lethargy, and fever to 39O C. On physical examination he had an erythematous pharynx, bilateral cervical adenopathy and an enlarged spleen. A cervical lymph node biopsy was performed. Your images are from the cervical lymph node.
|
|
Diagnosis & discussion |
|
|
|
|
Case 4
Presented by: Prof. Dr. Mine Hekimgil
Clinical History
A 50-year-old Caucasian woman, with a history of total gastrectomy for gastric diffuse large B-cell lymphoma performed six years ago. She had received CHOP chemotherapy following the diagnosis. Her disease relapsed two years later with stage IVB disease. She presented with weight loss, intraabdominal lymphadenopathy, and bone marrow involvement. She was in complete remission after three doses of R-ASHAP salvage chemotherapy and then autologous peripheral stem cell transplantation was performed.
She was seen by her physician due to symptoms that had developed gradually within three months, including tiredness, lack of appetite, weight loss, tingling of hands and feet, headache, pale skin color, palpitations, and depression. Pancytopenia, decreased reticulocyte count, elevated lactate dehydrogenase (LDH) and indirect bilirubin levels were identified on laboratory studies. Peripheral blood examination revealed macrocytosis, poikilocytosis and anisocytosis in red blood cells. The bone marrow aspirate and biopsy was submitted for further evaluation of infiltration of the bone marrow by lymphoma, secondary MDS or AML.
|
|
Diagnosis & discussion |
|
|
|
|
|
|
|
 |
 |
 |
|
