Clinicopathological Congress August 27, 2009 Nordic Society of Nephrology 30th Anniversary Congress
Case 1 EM
Case 1: Dr. Ole Wirta and Dr. Anne Räisänen-Sokolowski
Female, 35 years.
Clinical Fabry's disease. Marginal albuminuria, otherwise no signs or symptoms of renal disease. Renal biopsy performed on neurologists request to assess the need for treatment.
Immunofluorescence: Bright mesangial, granular IgA deposits, less intensive IgM and C3 with similar pattern and location.
Electron micrograph: Glomerular podocyte with large electron-dense myelin figures.
Case 2: Dr. Willy Aasebø and Dr. Erik Heyerdahl Strøm
Six years earlier he developed nephritis with SCr 120 and was C-ANCA positive. A renal biopsy showed a focal segmental necrotizing glomerulonephritis consistently with morbus Wegener. He was treated in hemodialysis for four years until he received a kidney transplant.
Two years and 11 months later he developed increasing dyspnea, edema, anemia, increasing creatinine and eventually fever. A graft biopsy was performed.
Case 3: Dr. Hans Dieperink and Dr. Niels Marcussen
36-years old male, Native kidney disease membranoproliferative glomerulonephritis, LRD kidney, First Tx. A total of 6 biopsies during 4 months. Graftectomy 4 months after Tx.
Graft biopsy #3a is performed 38 days post-tx due to increased s-creatinine (293 micromol/l) Graft biopsy #3b is performed 61 days post-tx, s-creatinine 560.
Graft biopsy #3c is performed 108 days post tx. Pt. in dialysis.
Graftectomy specimen #3d months post-tx.