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21st European Congress of Pathology Istanbul, Turkey, September 08-13, 2007 http://www.ecp2007istanbul.org/ Slide Seminar 10, September 12th Benign Hematopoetic Proliferations Mimicking Malignancies and Borderline Lymphoproliferative Lesions
Chairpersons: P. Kurtin, İ. Kuzu |
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Return to seminar page |
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Case 4
Presented by: Prof. Dr. Mine Hekimgil
Clinical History A 50-year-old Caucasian woman, with a history of total gastrectomy for gastric diffuse large B-cell lymphoma performed six years ago. She had received CHOP chemotherapy following the diagnosis. Her disease relapsed two years later with stage IVB disease. She presented with weight loss, intraabdominal lymphadenopathy, and bone marrow involvement. She was in complete remission after three doses of R-ASHAP salvage chemotherapy and then autologous peripheral stem cell transplantation was performed.
She was seen by her physician due to symptoms that had developed gradually within three months, including tiredness, lack of appetite, weight loss, tingling of hands and feet, headache, pale skin color, palpitations, and depression. Pancytopenia, decreased reticulocyte count, elevated lactate dehydrogenase (LDH) and indirect bilirubin levels were identified on laboratory studies. Peripheral blood examination revealed macrocytosis, poikilocytosis and anisocytosis in red blood cells. The bone marrow aspirate and biopsy was submitted for further evaluation of infiltration of the bone marrow by lymphoma, secondary MDS or AML.
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MEGALOBLASTIC ANEMIA
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28.12.2007 |
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