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21st European Congress of Pathology
Istanbul, Turkey, September 08-13, 2007
http://www.ecp2007istanbul.org/
Slide Seminar 13, September 10th
Unexpected histological findings that change the clinical diagnosis in foetoplacental pathology
Chairpersons: P.B.Nunes and E.Ozer |
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Return to seminar page |
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Case 7
Presented by: Dr. Phil Cox
Clinical History
N567/06: Neonatal death of a 4 day old male infant born at 34 weeks gestation. Mother is North African, G2 P0+1, having had one previous miscarriage. No significant medical or family history. Pregnancy was booked abroad. She was found to have symptoms of pre-eclampsia at 34 weeks gestation and was delivered the same day by Caesarean section. Birth weight 1490g, Apgars 8 at 1min and 10 at 5 mins. He was well until day 3 when he was found pale, grey and unsettled and tests showed a metabolic acidosis. He was found to have suffered pulmonary haemorrhage and was intubated and ventilated and received full resuscitation, transfusion, vitamin K, FFP and saline boluses. Initially he stabilised, but about 4 to 6 hours later he developed severe metabolic acidosis which was refractory to treatment. The cranial ultrasound scan showed echodensities in the frontal and occipital regions. He died on day 4 of life.
Macroscopic findings: A male infant whose birth weight is well below the 1st centile for 34/40 week gestation. Mild generalised oedema and jaundice. Small dark brown nodular liver. Gastric mucosal haemorrhage. Bilateral pulmonary haemorrhage. Section of liver.
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NEONATAL HAEMOCHROMATOSIS
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28.12.2007 |
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