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Tuesday slide seminar, February 10th 2009
Anu Mäkelä
Division of Pathology, HUSLAB, University Central Hospital, Helsinki, Finland
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Return to seminar page |
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Case 1
37 F. Suspicion of malignant pleuritis. Core needle biopsy from tumorous pleura.
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Sarcoma, high grade
Malignant peripheral nerve sheath tumor? |
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Discussion: Immunohistochemistry: S-100 +, laminin +, CD99 +, CD34 -, HMB-45 -, MART-1 -, desmin -, SMA -, MIB-1 up to 70 %. The result of karyotype analysis favored the diagnosis of MPNST. For some months the patient had suffered from intensive pain in the left heel, which was later shown to be caused by a distinctly rounded 4 cm tumor in the foot near posterior tibial nerve. Coarse needle biopsy was taken and the diagnosis of atypical schwannoma was made due to locally positive p53 staining and increased proliferation index (MIB-1 up to 20%). The patient died after six months from the diagnosis of the pleural tumor. The connection between the pleura and foot tumor remained unclear. |
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