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Tuesday slide seminar, February 10th 2009
Anu Mäkelä
Division of Pathology, HUSLAB, University Central Hospital, Helsinki, Finland
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Case 5
78 F. Slowly growing node of thyroid gland.
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Follicular carcinoma (with features of medullary carcinoma) |
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Immunohistochemistry : thyroglobulin +, TTF-1 +, AE1/AE3 +, CD56 +, CK7 + (weak), calcitonin-, synaptophysin -, chromogranin -, CK19 -, CEA -, PTH -, MIB-1 up to 10%. The patient had previously undergone strumectomy, parathyroid exploration and thyroid resection due to adenoma. During several years slow growth of the left thyroid lobe was followed and follicular neoplasia suspected in repeated fine needle samples (cytologically Papanicolau grading 2-3). The fourth neck operation was made after the patient developed symptoms of compression. In histological re- evaluation of the adenoma, the present tumor was found to be similar to the tumor operated in 1995. Thus, the tumor had grown slowly during 13 years. No metastasis was found. |
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