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Tuesday slide seminar, April 28th 2009
Maarit Tanskanen
Division of Pathology, HUSLAB, University Central Hospital, Helsinki, Finland
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Case 1
58 M. Down syndrome. Cause of death: bronchopneumonia. Brain macroscopy: frontotemporal and hippocampus atrophy, fits in Down syndrome. Sample: temporal neocortex
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Diagnosis & discussion |
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Case 2
72 F. 5 months previously intracerebral hemorrhage (ICH), resulting in right hemiparesis and dysphasia. Thereafter epileptic attack, condition deteriorated. Brain macroscopy: tentorial herniation, several cortical IHCs (3-6 cm). Sample: frontal neocortex (old hemorrhage).
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Diagnosis & discussion |
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Case 3
35 M. Cramp one week ago. CT and MRI: multiple non -specific lesions (infection/ tumor?). HIV +, syphilis antibody titer ?. Blood culture: Staf. aureus. Brain biopsy sample.
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Diagnosis & discussion |
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Case 4
76F M. Hypertension. Memory decline. EEG: periodic synchronous discharges, leading to a strong clinical CJD suspicion. Limited skull brain autopsy. Brain macroscopy: mild gyral frontotemporal atrophy, no focal changes. Sample: temporal neocortex.
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Diagnosis & discussion |
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Case 5
78 F. Fast proceeding dementia. No supporting clinical findings for CJD. Clinical conclusion: AD. Brain macroscopy: frontotemporal and entorrhinal cortical atrophy, small hippocampi. AD? Sample: hippocampus.
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Diagnosis & discussion |
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Case 6
81 M. Morbus Parkinson. Lewy body dementia suspected. Cause of death: pulmonary embolism. Brain macroscopy: substantia nigri clearly light, no cortical atrophy, hippocampi slightly small. Sample: mesencefalon.
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Diagnosis & discussion |
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