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| Title: |
Cytokeratin 5/14-positive breast cancer: true basal phenotype confined to BRCA1 tumors |
| Authors: |
Mervi Laakso, Niklas
Loman, Åke Borg and Jorma Isola |
| Journal: |
Modern Pathology 2005 Oct;18(10):1321-8. |
| Pubmed: |
PMID: 15990899 |
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Figure 1-4.
Four invasive ductal breast cancers stained with CK5/CK14/p63 antibody cocktail and separately with each of the mAbs, CK5, CK14 and p63, are shown. The antibody cocktail CK5/CK14/p63 recognizes CK5/14-positive basal phenotype breast cancers, which represent almost 9% of invasive ductal breast cancers and are mostly aggressive hormone receptor negative grade III tumors. Transcription factor p63-positive tumors are rare and showed no connection to CK5/14-positivity.
Note: only standard jpg versions available
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Figure 5.
Primary carcinoma versus metastasis pairs of two (A and B) invasive ductal carcinomas of the breast stained with CK5/CK14/p63 antibody cocktail. Tumor A shows CK5/14 immunopositivity in both primary tumor and metastasis. Carcinoma B shows no expression of cytokeratins 5 and 14 or transcription factor p63 in the primary tumor or in metasynchronous metastasis. All pairs of primary and metastatic tumors showed concordant results (four CK5/14-positive cases out of 38).
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Figure 6
Three BRCA1 germ-line mutated tumors stained with CK5/CK14/p63 and CK8/18 are shown. Almost 80 % of BRCA1 germ-line mutated tumors are immunopositive for cytokeratins 5/14 representing the basal phenotype breast cancer (tumors A and C). Tumor B shows luminal CK5/14-negative and CK8/18-positive phenotype. In BRCA1 mutated CK5/14-positive breast cancers luminal cytokeratin 8/18 intensity can be lowered (tumor C) and also totally CK8/18-negative BRCA1 tumors positive for CK5/14 are seen (tumor A), while all sporadic tumors despite of the CK5/14 expression are CK8/18-positive. Tumor C also shows nuclear transcription factor p63 positivity.
Note: only standard jpg versions available |
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